SiliaBond^® Carbamate (CAR) is a versatile scavenger for nucleophiles. It readily scavenges amines, thiols, thiolates, alcohols, alkoxides, and acidic phenols. Loading is determined by the removal of benzylamine in hexane at room temperature.

Si-CAR has been used to scavenge amines in a “cap-tag” methodology for oligosaccharide preparation by automated solid phase synthesis¹ and in the preparation of 2,5-diketopiperazines and 1,4-benzodiazepine-2,5-diones.²

Silica supported Carbamate has superior reactivity in a broader range of solvents when compared to polymer-based materials.

RELATED PUBLICATIONS

1. Angew. Chem. Int. Ed., 40 (2001) 4433
2. Org. Lett., 4 (2002) 1167

SiliaBond^® Piperidine (Si-PIP) is a general purpose tertiary amine base to scavenge acids, thereby avoiding salt elimination problems. Also used as a base catalyst for Knoevenagel condensation.

PRODUCT SPECIFICATIONS

MSDS-R71530B

Supported sulfonic acids such as SiliaBond^® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.

SiliCycle offers SiliaBond Propylsulfonic Acid (SCX-2) and SiliaBond Tosic Acid (SCX). Both are considered strong cation exchanger as they maintain a negative charge throughout the pH scale. The aromatic ring of the SiliaBond Tosic Acid makes it slightly more acidic than the other. However, tests have demonstrated that they both have comparable strength. The difference between the two products is mainly in the selectivity. SiliaBond SCX-2 presents a slightly more non-polar character than the SiliaBond SCX, thus reducing secondary non-polar interactions with compounds.

PRODUCT SPECIFICATIONS

MSDS-R51230B

APPLICATION NOTES
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POSTERS
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RELATED PUBLICATION

1. Electrochem. Comm., 11 (2009) 305