品名：G418 SULFATE
CAS Number: 108321-42-2
性状：白色粉末
存储温度：2 to 6°C
分子式: C20H40N4O10·2H2SO4
分子量: 692.7
溶剂：溶于水
用途：G418是一种氨基糖苷类抗生素，通过干扰核糖体的功能而阻断细胞的蛋白合成。在基因转移、基因敲除、抗性筛选以及转基因动物等方面得以广泛应用，是稳定转染最常用的抗性筛选试剂。
产品信息
|
品牌 |
货号 |
品名 |
规格 |
促销价 |
|
phytotech |
G810 |
G418 SULFATE |
1G |
438 |
|
phytotech |
G810 |
G418 SULFATE |
5G |
2083 |
|
phytotech |
G810 |
G418 SULFATE |
10G |
3483 |
G418 is an aminoglycoside antibiotic. Unlike other aminoglycoside, G418 is more potent because it contains a hydroxyl function at C-6’ position rather than an amino function. It binds directly to the 80S ribosomal subunit and inhibits protein synthesis of eukaryotic cells.1 G418 is effective against aerobics and facultative Gram-negative bacilli, and some Gram-positive bacteria.
In molecular biology application, G418 sulfate is often used as a selection agent
Please Note: It is the sole responsibility of the purchaser to determine the appropriateness of this product for the specific plants that are being cultured and applications that are being used.
References
1. Marie-Paule Mingeot-Leclercq, Youri Glupczynski, and Paul M. Tulkens. 1999. Aminoglycosides: Activity and Resistance. Antimicrob Agents Chemother. Vol 43(4). Pp. 727-737.
2. Xie, D. and Y. Hong. 2002. Agrobacterium-mediated genetic transformation of Acacia mangium. Plant Cell Reports. Vol 20(10). Pp. 917-922.
3. P. A. Lazzeri, R. Brettschneider, R. Lührs, and H. Lörz. 1991. Stable transformation of barley via PEG-induced direct DNA uptake into protoplasts. Theoretical and Applied Genetics. Vol 81(4). Pp. 437-444.
4. Christine Lang-Hinrichs, Dietmar Berndorff, Carsten Seefeldt, and Ulf Stahl. 1989. G418 resistance in the yeast Saccharomyces cerevisiae: comparison of the neomycin resistance genes from Tn5 and Tn903. Applied Microbiology and Biotechnology. Vol 30(4). Pp. 388-394.
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