IL-22 (C-6His), Human, Recombinant
货号:PCK184
价格:¥1780¥4980¥18980¥27980
别名 |
Interleukin-22; IL-22; Cytokine Zcyto18; IL-10-related T-cell-Derived-inducible factor; IL-TIF |
物种 |
Human |
表达宿主 |
Human Cells |
序列信息 |
asd |
检索号 |
Q9GZX6 |
分子量 |
17.7 kDa |
表观分子量 |
25-35 kDa |
生物活性 |
Testing in progress |
纯度 |
>95% as determined by reducing SDS-PAGE. |
内毒素 |
< 1.0 EU per µg as determined by LAL test. |
保存 |
Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. |
运输 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
复融 |
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Interleukin-22 (IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 Receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 Receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding Protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by Cytokine IL-17A.
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