IL-31, Human, Recombinant
货号:PCK190
价格:¥1780¥4980¥24080¥35580
别名 |
Interleukin-31; IL-31; IL31 |
物种 |
Human |
表达宿主 |
E.coli |
序列信息 |
asd |
检索号 |
Q6EBC2 |
分子量 |
15.8 kDa |
表观分子量 |
15 kDa |
生物活性 |
Measured by inducing STAT3 activation in U87 MG human glioblastoma/ astrocytoma cells.The ED50 for this effect is less than 45 ng/ mL. |
纯度 |
>95% as determined by reducing SDS-PAGE. |
内毒素 |
< 1.0 EU per µg as determined by LAL test. |
保存 |
Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
运输 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
制剂 |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
复融 |
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Human Interleukin 31 (IL-31) is a Cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature Protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric Receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M Receptor (OSM Rβ). The IL-31 Receptor is constitutively expressed by keratinocytes and upregulated by IFNγ on monocytes. GPL/ OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.
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