HGF R/ c-Met/ HGFR, Human, Recombinant
货号：PCK028
价格：¥780¥1880¥8680¥12380
| 别名 |
Hepatocyte Growth Factor Receptor; HGF Receptor; HGF/ SF Receptor; Proto-oncogene c-Met; Scatter factor Receptor; SF Receptor; Tyrosine- Protein kinase Met; MET |
| 物种 |
Human |
| 表达宿主 |
Human Cells |
| 序列信息 |
asd |
| 检索号 |
P08581 |
| 分子量 |
102.5 kDa |
| 表观分子量 |
80-94&130 kDa |
| 标签 |
C-6His |
| 生物活性 |
Testing in progress |
| 纯度 |
>95% as determined by reducing SDS-PAGE. |
| 内毒素 |
< 1.0 EU per µg as determined by LAL test. |
| 保存 |
Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 |
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Hepatocyte Growth Factor Receptor (HGF R) is a glycosylated Receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. Mature HGF R is a disulfide-linked dimer composed of a 50 kDa extracellular α chain and a 145 kDa transmembrane β chain. Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domain, consist of secreted extracellular domains, or are deficient in proteolytic separation of the α and β chains. The sema domain, which is formed by both α and β chains of HGF R, mediates both Ligand binding and Receptor dimerization. HGF stimulation induces HGF R downregulation via internalization and proteasomedependent degradation. Paracrine induction of epithelial cell scattering and branching tubulogenesis results from the stimulation of HGF R on undifferentiated epithelium by HGF released from neighboring mesenchymal cells.
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