Dehydroepiandrosterone (DHEA) 去氢表雄酮

Dehydroepiandrosterone (DHEA) 去氢表雄酮

货号: JP1224-5G 品牌: Jinpan 标签: 生化试剂

描述

Dehydroepiandrosterone (DHEA)去氢表雄酮

产品关键词

Dehydroepiandrosterone (DHEA)去氢表雄酮;脱氢表雄甾酮;Androstenolone雄甾烯二酮;GABAA受体调节剂;Steroid hormone类固醇激素;CAS NO:53-43-0;

产品信息

产品名称

产品编号

规格

   价格(元)

            Dehydroepiandrosterone (DHEA)去氢表雄酮                     JP1224-1G                   1g                 180
            Dehydroepiandrosterone (DHEA)去氢表雄酮      JP1224-5G           5g       580

产品描述

去氢表雄酮(Dehydroepiandrosterone, DHEA)是一种重要的内源性类固醇激素(甾体激素),用作雌激素和雄激素生物合成的代谢中间物。通过结合到细胞核和细胞表面受体发挥着各种潜在的生理效应。还是一种神经类固醇。

产品特性

1) CAS NO:53-43-0

2) 化学名:(3S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16- dodecahydrocyclopenta[a]phenanthren-17-one 

3) 同义名:trans-Dehydroandrosterone; DHEA; didehydroepiandrosterone; 3β-Hydroxy-5-androsten-17-one; 5-Androsten-3β-ol-17-one; androstenolone; Prasterone; 脱氢表雄甾酮;雄烯醇酮;反式-脱氢异雄甾酮;脱氢表雄甾酮;

4)分子式:C19H28O2

5)分子量:288.42 g/mol

6)外观:白色至类白色固体粉末

7) 纯度:≥99%

8)溶解性:溶于DJPO(≥10mg/ml),微溶于水【注】:≥表示该化合物溶解度大于等于标示浓度,但饱和溶解度未知。

9)化学结构式:

Dehydroepiandrosterone (DHEA) 去氢表雄酮

保存与运输方法

保存:2-8℃干燥保存,2年有效;-20℃干燥保存,3年有效。

运输:常温运输。

注意事项

  1. 本品不是临床药物,只能用于科研用途,不能用于诊断或临床用途。
  2. 为了您的安全和健康,请穿实验服并戴一次性手套操作。

储存液制备

Dehydroepiandrosterone (DHEA) 去氢表雄酮

使用方法【源自文献,仅作参考】

文献1,Yoon SY et al. Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABAA receptors. Br J Pharmacol. 2009 Jun;157(4):666-73.PMID: 19422393

体内研究(动物模型):

动物模型(Animal Model):Male ICR mice (24–30 g)

药物配制(Preparation):DHEA and progesterone were diluted in 1% DJPO in corn oil. DHEAS was diluted in 1% DJPO in saline.

给药剂量(Dosage):Drugs were dissolved in 5 µL of vehicle.Intrathecal injections (5 µL volume) were made into the L5-L6 intervertebral space of unanaesthetized mice using a 10 µL Hamilton syringe connected to a 30-gauge needle. The control group received an i.t. injection of vehicle.

目的与结果(Results):To study the effect of DHEASand DHEAon the nociceptive threshold to mechanical stimulation.i.t. injection of DHEAS (150, 300 or 600 pmol) dose-dependently decreased withdrawal threshold to mechanical stimulation compared with that of the vehicle control group. Conversely,i.t. injection of DHEA (0.1, 10 and 1000 nmol per mouse)had no effect on the mechanical nociceptive threshold, even at the highest dose.

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规格信息

品牌:

Jinpan

CAS:

53-43-0

规格:

5g

货期:

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