IL-6Rα/ CD126, Human, Recombinant
货号：PCK202
价格：¥1280¥2980¥17480¥25680
规格：
10µg
- 10µg
- 50µg
- 500µg
- 1mg
- 产品概述
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产品概述
产品信息
| 别名 | Interleukin-6 Receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6R 1; Membrane glyco Protein 80; gp80; CD126 |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | asd |
| 检索号 | NP_000556.1 |
| 分子量 | 38.9 kDa |
| 表观分子量 | 60 kDa |
| 标签 | C-6His |
| 生物活性 | Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL-6 at 8 μg/ mL (100 μl/ well) can bind recombinant human IL6R with a linear range of 1.25-20.0 ng/ ml.2. Measured by its ability to enhance the IL6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 20-80 ng/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Interleukin 6 is a potent pleiotropic Cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the Receptor for Interleukin 6 Cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 Receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this Receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
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