Iba1是在小胶质细胞和巨噬细胞中高度表达的蛋白质，分子量约17 kDa。 此蛋白质通常称为中枢神经系统中的小胶质细胞标记物。

　　最近，小胶质细胞已被广泛研究，其负责中枢神经系统中的免疫功能，并且与各种疾病相关，如神经变性疾病，精神错乱，脑肿瘤和感染。

抗Iba1，单克隆抗体（NCNP24）

抗原

合成肽（Iba1的C末端）

克隆号

NCNP24

子类

小鼠IgG1

浓度

1.3 mg/mL

Buffer缓冲液

50％甘油/ TBS，0.05％叠氮化钠

物种反应性

小鼠，大鼠，狨猴

应用

免疫组织化学（冷冻切片）（1：500-2,000）

产品编号

产品名称

中文名称

包装

储存条件

016-26461

Anti Iba1, Rabbit, Biotin-conjugated

抗Iba1，兔，生物素缀合

100 μL

保存在2-10℃

013-26471

Anti Iba1, Rabbit, Red Fluorochrome   (635)-conjugated

抗Iba1，兔，红色荧光染料（635）结合

100 μL

012-26723,016-26721

说明书

1.

Moghaddam, B. (2018). Omega-3 Polyunsaturated Fatty Acid Status, Microglial Activation, Stress Resilience, and Cognitive Performance. Oregon Health and Science University Portland United States.

2.

Li, K., Zhou, H., Zhan, L., Shi, Z., Sun, W., Liu, D., … & Xu, E. (2018). Hypoxic preconditioning maintains GLT-1 against transient global cerebral ischemia through upregulating Cx43 and inhibiting c-Src. Frontiers in molecular neuroscience, 11.

3.

Gasparotto, J., Ribeiro, C. T., da Rosa-Silva, H. T., Bortolin, R. C., Rabelo, T. K., Peixoto, D. O., … & Gelain, D. P. (2019). Systemic inflammation changes the site of RAGE expression from endothelial cells to neurons in different brain areas. Molecular neurobiology, 56(5), 3079-3089.

4.

Wanrooy, B. J., Kumar, K. P., Wen, S. W., Qin, C. X., Ritchie, R. H., & Wong, C. H. (2018). Distinct contributions of hyperglycemia and high-fat feeding in metabolic syndrome-induced neuroinflammation. Journal of neuroinflammation, 15(1), 293.

5.

Velazquez, R., Ferreira, E., Winslow, W., Dave, N., Piras, I. S., Naymik, M., … & Oddo, S. (2019). Maternal choline supplementation ameliorates Alzheimer’s disease pathology by reducing brain homocysteine levels across multiple generations. Molecular psychiatry, 1.

6.

Sanchez-Ruiz, M., Brunn, A., Montesinos-Rongen, M., Rudroff, C., Hartmann, M., Schlüter, D., … & Deckert, M. (2019). Enteric Murine Ganglionitis Induced by Autoimmune CD8 T Cells Mimics Human Gastrointestinal Dysmotility. The American journal of pathology, 189(3), 540-551.

7.

Cougnoux, A., Fellmeth, M., Gu, T., Davidson, C. D., Gibson, A. L., Pavan, W. J., & Porter, F. D. (2019). Maternal immune activation modifies the course of Niemann-pick disease, type C1 in a gender specific manner. Molecular genetics and metabolism.

8.

Groves, A., Kihara, Y., Jonnalagadda, D., Rivera, R., Kennedy, G., Mayford, M., & Chun, J. (2018). A functionally defined in vivo astrocyte population identified by c-Fos activation in a mouse model of multiple sclerosis modulated by S1P signaling: immediate-early astrocytes (ieAstrocytes). eNeuro, 5(5).

9.

Cai, W., Wang, J., Hu, M., Chen, X., Lu, Z., Bellanti, J. A., & Zheng, S. G. (2019). All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling. Journal of neuroinflammation, 16(1), 175.

10.

Feng, T., Yamashita, T., Shang, J., Shi, X., Nakano, Y., Morihara, R., … & Matsumoto, N. (2019). Clinical and Pathological Benefits of Edaravone for Alzheimer’s Disease with Chronic Cerebral Hypoperfusion in a Novel Mouse Model. Journal of Alzheimer's Disease, (Preprint), 1-13.

11.

Chen, Y. J., Nguyen, H. M., Maezawa, I., Jin, L. W., & Wulff, H. (2018). Inhibition of the potassium channel Kv1. 3 reduces infarction and inflammation in ischemic stroke. Annals of clinical and translational neurology, 5(2), 147-161.

12.

Michaelis, K. A., Norgard, M. A., Levasseur, P. R., Olson, B., Burfeind, K. G., Buenafe, A. C., … & Marks, D. L. (2019). Persistent Toll-like receptor 7 stimulation induces behavioral and molecular innate immune tolerance. Brain, behavior, and immunity, 82, 338-353.

13.

Surrao, D. C., Greferath, U., Chau, Y. Q., Skabo, S. J., Huynh, M., Shelat, K. J., … & Liu, Q. (2017). Design, development and characterization of synthetic Bruch’s membranes. Acta biomaterialia, 64, 357-376.